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Journal Articles († co-first author; * corresponding author)


37. Haley L. Swanson, Chengchen Guo, Michael Cao, Bennett Addison and Gregory P. Holland*, Probing the Binding Modes and Dynamics of Histidine on Fumed Silica Surfaces by Solid-state NMR. Phys. Chem. Chem. Phys. 2020 (Accepted)

36. Xiuli Wang†*, Chengchen Guo†, Lina Guo, Yizhe Song, Ming Liu, Yanfang Ding, Xiaoqing Wei, Zinan Zhao, Hui Jiao, David L. Kaplan*, Radially Aligned Porous Silk Fibroin Scaffolds as Functional Templates for Engineering Human Biomimetic Hepatic Lobules. (submitted)

35. Feng Wang†, Chengchen Guo†, Chunmei Li, Ping Zhao, Qingyou Xia*, David L. Kaplan*, Protein composites from silkworm cocoons as versatile biomaterials. (submitted)

34. Yushu Wang, Wenwen Huang, Yu Wang, Xuan Mu, Shengjie Ling, Haipeng Yu, Wenshuai Chen, Chengchen Guo, Matthew Watson, Yingjie Yu, Lauren D. Black, Meng Li, Fiorenzo G. Omenetto, Chunmei Li*, David L. Kaplan*, Stimuli-responsive composite biopolymer actuators with selective spatial deformation behavior. Proc. Natl. Acad. Sci. U.S.A 2020, 117, 14602-14608

33. Chengchen Guo, Chunmei Li, David L. Kaplan*, Enzymatic Degradation of Bombyx mori Silk Materials: A Review. Biomacromolecules 2020, 21, 5, 1678-1686

32. Rachael N. Parker, Dana M. Cairns, Wenyao A. Wu, Kathryn Jordan, Chengchen Guo, Wenwen Huang, Zaira Martin-Moldes, David L. Kaplan*, Smart Material Hydrogel Transfer Devices Fabricated with Stimuli-Responsive Silk-Elastin-Like Proteins. Adv. Healthcare. Mater. 2020, 2000266.

31. Ying Chen†, Chengchen Guo†, Eleana Manousiouthakis, Xiuli Wang, Dana M. Cairns, Terrence Roh, Chuang Du, David L. Kaplan*, Bi-layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue. Adv. Funct. Mater. 2020, 2000543.

30. Chengchen Guo, Chunmei Li, Xuan Mu, David L. Kaplan*, Engineering Silk Materials: From Natural Spinning to Artificial Processing. Appl. Phys. Rev. 2020, 7, 011313

29. Chengchen Guo†, Chunmei Li†*, Hiep V. Vu, Philip Hanna, Aron Lechtig, Yimin Qiu, Xuan Mu, Shengjie Ling, Ara Nazarian, Samuel Lin, David L. Kaplan*, Thermoplastic Moulding of Regenerated Silk. Nat. Mater. 2020, 19, 102-108.

28. Chunmei Li†*, Chengchen Guo†, Vincent Fitzpatrick, Ahmed Ibrahim, Myrthe Zwierstra, Philip Hanna, Aron Lechtig, Ara Nazarian, Samuel Lin, and David Kaplan*, Design of biodegradable implantable devices towards clinical translation. Nat. Rev. Mater. 2020, 5, 61-81.

27. Xiuli Wang*, Chengchen Guo, Ying Chen, Lorenzo Tozzi, Sophia Szymkowiak, Chunmei Li, David L. Kaplan*, Developing A Self-organized Tubulogenesis Model of Human Renal Proximal Tubular Epithelial Cells in vitro. J. Biomed. Mater. Res. A 2020, 3, 795-804.

26.Xuan Mu, Yu Wang, Chengchen Guo, Yamin Li, Shengjie Ling, Wenwen Huang, Peggy Cebe, Huan-Hsuan Hsu, Fabio De Ferrari, Xiaocheng Jiang, Qiaobing Xu, Alessandra Balduini, Fiorenzo G. Omenetto, David L. Kaplan*, 3D Printing of Silk Protein Structures by Aqueous Solvent‐Directed Molecular Assembly. Macromol. Biosci. 2020, 20, 1900191.

25. Palash Mondal*, Chengchen Guo, Jeffery L. Yarger*, Water Soluble Gold-polyaniline Nanocomposite: A Substrate for Surface Enhanced Raman Scattering and Catalyst for Dye Degradation. Arab. J. Chem. 2020, 13, 4009.


24. Terrence Roh, Ying Chen, Harry Paul, Chengchen Guo, David L. Kaplan*, 3D Bioengineered Tissue Model of the Large Intestine to Study Inflammatory Bowel Disease. Biomaterials 2019, 225, 119517.

23. Siwei Zhao, Chengchen Guo, Allison Kumarasena, Fiorenzo G. Omenetto, David L. Kaplan*, 3D Printing of Functional Microalgal Silk Structures for Environmental Applications. ACS Biomater. Sci. Eng. 2019, 5, 4808.

22. Xiuxia Sun, Zhao Liu, Sha Zhao, Xiaojun Xu, Shenlin Wang, Chengchen Guo, Jianxi Xiao*, A Self-assembling Collagen Mimetic Peptide System to Simultaneously Characterize the Effects of Osteogenesis Imperfecta Mutations on Conformation, Assembly and Activity. J. Mater. Chem. B 2019, 7, 3201.

21. Geraldine Polido, Xiangyan Shi, Dian Xu, Chengchen Guo, Rich Thai, Joseph P Patterson, Nathan C Gianneschi, Thomas M Suchyna, Frederick Sachs, Gregory P Holland*, Investigating the Interaction of Grammostola rosea Venom Peptides and Model Lipid Bilayers with Solid-state NMR and Electron Microscopy Techniques. Biochim. Biophys. Acta, Biomembranes 2019, 1861, 151.


20. Morgan J. Hawker, Chengchen Guo, Fiorenzo G. Omenetto, David L. Kaplan*, Solvent-free Strategy to Encapsulate Degradable, Implantable Metals in Silk Fibroin. ACS Applied Bio Materials 2018, 1, 1677.

19. Russell Urie, Chengchen Guo, Deepanjan Ghosh, Mitzi Thelakkaden, Valerie Wong, Jung Keun Lee, Jacquelyn Kilbourne, Jeffery Yarger, Kaushal Rege*, Rapid Soft Tissue Approximation and Repair using Laser-Activated Nanosealants. Adv. Funct. Mat. 2018, 28, 1802874.

18. Dong An*, Chengchen Guo, Yanan Chen, Analysis of Polycyclic Aromatic Hydrocarbon (PAH) Mixtures Using Diffusion-Ordered NMR Spectroscopy and Adsorption by Powdered Activated Carbon and Biochar. Materials 2018, 11, 460.

17. Chengchen Guo*, Jin Zhang, Jacob S Jordan, Xungai Wang, Robert W Henning, Jeffery L Yarger*, Structural Comparison of Various Silkworm Silks: An Insight into the Structure-Property Relationship. Biomacromolecules 2018, 19, 906. (* Co-corresponding author)

16. Chengchen Guo*, Jeffery L Yarger*, Characterizing Gold Nanoparticles by NMR Spectroscopy. Magn. Reson. Chem. 2018, 11, 1074. (* Co-corresponding author)


15. Chengchen Guo, Jin Zhang*, Wang Xungai, Anh Tuan Nguyen, Xiang Yang Liu, David L Kaplan*, Comparative Study of Strain-Dependent Structural Changes of Silkworm Silks: Insight into the Structural Origin of Strain-Stiffening. Small 2017, 13, 1702266.

14. Daniel Finkelstein-Shapiro, Maxime Fournier, Dalvin Méndez-Hernández, Chengchen Guo, Monica Calatayud, Thomas A. Moore, Ana L. Moore, Devens Gust, Jeffery L. Yarger, Valdimiro Mujica*, Understanding Iridium Oxide Nanoparticle Surface Sites by their Interaction with Catechol. Phys. Chem. Chem. Phys2017, 19, 16151.

13. Chengchen Guo*, Jacob S. Jordan, Jeffery L. Yarger, Gregory P. Holland*, Highly Efficient Fumed Silica Nanoparticles for Peptide Bond Formation: Converting Alanine to Alanine Anhydride. ACS Appl. Mater. Interfaces 2017, 9, 17653. (* Co-corresponding author)

Prior to 2017

12. Geoffrey M. Gray, Arjan van der Vaart, Chengchen Guo, Justin Jones, David Onofrei, Brian R. Cherry, Randolph V. Lewis, Jeffery L. Yarger, Gregory P. Holland*, Secondary Structure Adopted by the Gly-Gly-X Repetative Regions of Dragline Spider Silk, Int. J. Mol. Sci. 2016, 17, 2023.

11. Daniel Finkelstein-Shapiro, Stephen K. Davidowski, Paul Lee, Chengchen Guo, Gregory P. Holland, Tijian Rajh, Valdimiro Mujica, Kimberly A. Gray, Jeffery L. Yarger, Monica Calatayud*, Direct Evidence of Chelated Geometry of Catechol on TiO2 by a Combined Solid-state NMR and DFT Study. J. Phys. Chem. C 2016, 120, 23625.

10. Chengchen Guo, Gregory P. Holland, Jeffery L. Yarger*, Lysine-capped Silica Nanoparticles: A solid-state NMR Spectroscopy Study. MRS Advance 2016, 31, 2261.

9. Chengchen Guo, Gregory P. Holland*, Alanine Adsorption and Thermal Condensation at the Interface of Fumed Silica Nanoparticles: A Solid-state NMR Investigation. J. Phys. Chem. C 2015, 119, 25663. 

8. Carmen Guzman, Rafael Calderon, Zhong Li, Shiori Yamazaki, Samuel Peurifoy, Chengchen Guo, Stephen Davidowski, Mercedes Mazza, Xu Han, Gregory Holland, Amy Scott, Adam Braunschweig*, Extended Charge Carrier Lifetimes in Hierarchical Donor-Acceptor Supramolecular Polymer Films. J. Phys. Chem. C 2015, 119, 19584.

7. Dian Xu, Chengchen Guo, Gregory P. Holland*, Probing the Impact of Acidification on Spider Silk Assembly Kinetics. Biomacromolecules 2015, 16, 2072. 

6. Haobo Chen, Morgan Kelly, Chengchen Guo, Jeffery L. Yarger, Lenore L. Dai*, Adsorption and Release of Surfactant into and from Multifunctional Zwitterionic Poly(NIPAm-co-DMAPMA-co-AAc) Microgel Particles. J. Colloid Interface Sci. 2015, 449, 332.

5. Chengchen Guo, Genevieve N. Hall, John B. Addison, Jeffery L. Yarger*, Gold Nanoparticle-doped Silk Film as Biocompatible SERS substrate. RSC Adv. 2015, 5, 1937. 

4. Chengchen Guo, Gregory P. Holland*, Investigating Lysine Adsorption on Fumed Silica Nanoparticles. J. Phys. Chem. C 2014, 118, 25792.

3. Chunhong Yu, Lili Zhu, Rongchun Zhang, Xiaoliang Wang, Chengchen Guo, Pingchuan Sun, Gi Xue*, Investigation on the Mechanism of the Synthesis of Gold(I) Thiolate Complexes by NMR. J. Phys. Chem. C 2014, 118, 10434.

2. Xiangyan Shi, Chengchen Guo, Gregory P. Holland*, NMR Characterization of Spider Venom Neurotoxin Structure and Interactions with Lipid Bilayers. Biophysical J. 2014, 106, 294A

1. Lili Zhu, Chen Zhang, Chengchen Guo, Xiaoliang Wang, Pingchuan Sun, Dongshan Zhou, Wei Chen, Gi Xue*, New Insight into Intermediate Precursors of Brust-Schiffrin Gold Nanoparticles Synthesis. J. Phys. Chem. C 2013, 117, 11399.

Book Chapters

Chengchen Guo, Jeffery L. Yarger, Chapter 18: NMR Characterization of Silk. NMR Methods for Characterization of Synthetic and Natural PolymersRoyal Society of Chemistry (2019)